Abstract

Antagonist Narcotic an antagonist is used extensively as pharmacologic tools for the investigation of opioid receptors [12]. Indeed, the recent research literature attests to the impact that such antagonist have made in this previous active research area. However, the reversible nature of conventional narcotic antagonist e.g.,Naltrexone is an inherent limitation to its utility,particularly with regard to the use of such compound in the isolation and purification of opioid receptors.Naltrexone monotherapy was approved for the treatment of opioid addiction in 1984 and alcohol dependence in 1995.Additionally, Naltrexone is approved to treat heroin overdose and to reverse respiratory depression caused by morphine.Naltrexone is used to treat heroin and alcohol abuse. In previous study, were made to formulate a transdermal patch containing Naltrexone which has controlled release. Slow release is critically significant in drug delivery for minimizing the amount of drug lost before reaching the target. Shell structures and supports can be used for slow delivery of drugs and are usually made from organic materials.Forexample,liposomes [13-15],microspheres [16],polymericshells [17]and polymeric micelles [18-19]have been well investigated in constructing a drug delivery system from organic materials, the combination of shell or support materials, targetingmolecules, and drugs are restricted to ensure stability targeting efficiency,and drug effect.Although,many supporting polymers are expensive,this restriction can be reduced by using carbon nanotubes [20].On the other hand, nanomedicine, which is an emerging bridge linking nanotechnology and advanced medical technology involves the exploration of nano scaled materials with the aim of developing novel types of drug carriers, imaging agents,sensors,etc.[21-22]. Nanotubes have several properties that make them suitable for use a nanotube-supported drugs. Functionalized CNTs have been shown in many studies to be able to cross cell membranes [23-25]. The ability of CNTs to cross cell membranes allowing them to be used as carriers is of particular high interest for drug delivery strategies. The individuals which have used overdoses narcotics, if the opioid antagonist drug of Naltrexone is be given to them of the oral way, the patient is possible is be caused at first stage respiratory depression, heartattack, intense convulsion and the patient can be sometimes caused of the death. Therefore, we have used of solid support in this work. For the attachment antagonist drug of Naltrexone by different kinds of carbodiimides reagents, which it can be solid phase of carbon nanotube. The drug carrier of Naltrexone is assuming will be used as skin absorption in this work in the recent future, which the attachment drugs antagonist to carbon nanotubes will desire to absorb by the skin layers and hairs on the skin surface. It will suggest introduce as drug carrier to blood and there it can be transferred to the brain. The absorption opioid antagonist drug on the surface carbon nanotube by the covalent functionalization.it can be promised for reducing dangers of such as; respiratorydepression, heartattack, intenseconvulsive, death and etc.,In the recent future.