Abstract

The drugs of choice for the treatment of several pain are the opioids,the activities of which are mediated by their interaction with specific membrane round G-protein coupled receptors(GPCR)[1,2]. The existence of at least three major classes of opioid receptors, viz,µ,k, δ,has been well established [3].These receptors have also been cloned and functionally characterized[4-11].Naltrexone is a potent opioid antagonist with little agonist activity and its along activity opioid antagonist which is used in opiate addiction treatment and rehabilitation.Naltrexone is a mu-opioid receptor antagonist.Narcotic antagonist is used extensively as pharmacologic tools for the investigation of opioid receptors[12].indeed,the recent researchliterature attests to the impact that such antagonist have made in the previous active research area.How over, the reversible nature of conventional narcotic antagonist e.g.,Naltrexone is an inherent limitation to its utility,particularly with regard to the use of such compound in the isolation and purification of opioid receptors.Naltrexone monotherapy was approved for the treatment of opioid addiction in 1984 and alcohol dependence in 1995.Additionally,Naltrexone is approved to treat heroin overdose and to reverse respiratory depression caused by morphine.Naltrexone is used to treat heroin and alcohol abuse.In previous study,were made to formulate a transdermal patch containing Naltrexone which has controlled release.law release is critically significant in drug delivery or minimizing the amount of drug lost before reaching to target. Shell structures and supports can be used or slow delivery of drugs and are usually made from organic materials.For example,liposomes[13-15].Microspheres[16].polymeric shells[17]and polymeric micelles have been well investigated[18-19]. In constructing drug delivery system from organic materials,the combinations of shell or support materials,targeting molecules,and drugs are restricted to ensure stability targeting efficiency,and drug effect.Although,many supporting polymers are expensive,this restriction can be reduced by using carbon nanotubes[20].On the other hand,nano medicine,which is an emerging bridge linking nanotechnology and advanced medical technology involves the exploration of nanoscale materials with the aim of developing novel types of drug carriers,imaging agents,sensors,etc[21-22].Nanotubes have several properties that make them suitable for use a nanotube supported drugs.Functionalization CNTs have been shown in many studies to be able to cross cell membranes[23-25].The ability of CNTs to cross cell membranes allowing them to be used as carriers is of particular high interest for drug delivery strategies.The individuals which have used overdoses narcotics,if the opioid antagonist drug of Naltrexone is be given to them of the oral ways,the patient is possible is be caused at first stage respiratory depression,heart attack,intense convulsive and or the patient can be sometimes caused of the death.Therefore, we have used of solid support in this work for the attachment antagonist drug of Naltrexone which it can be solid phase of carbon nanotube.