Journal of Green Chemistry and Chemical Engineering

The attachment opioid antagonist drug of Naltrexone to multi-walled carbon nanotubes by different kinds of reagents carbodiimides

Mohammadreza Gholibeikian, Amirreza Arvaneh, Nastaran Gholami Samalic — Mon, 14 Mar 2022 00:00:00 +0000

Surface functionalization of multi-walled carbon nanotubes(MWCNTs) by opioid antagonist drug of Naltrexone via chemical modification of carboxyl groups,using of reagents di cyclohexyl carbodiimide(DCC),1-ethyl-3[3-dimethylaminopropyl] carbodiimide hydrochloride(EDC),N-hydroxysuccinimide(NHS),1-hydroxybenzotriazolemonohydrate(HOBT),O-(Benzotriazole-1-yl)-1,1,3,3-tetramethyluraniumtetrafluoroborate(TBTU),were performed. In synthetic organic chemistry,compounds containing the carbodiimide functionality are dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Carboxylic acids will react with the carbodiimide to produce the key intermediate as O-acylisourea which can be considered as a carboxylic ester with an activated leaving group.We have used of five carbodiimide reagent to synthesis twelve sample in this work.The resulting materials were characterized by different techniques,such as Fourier transform infraredspectroscopy (FT-IR), Thermogravimetricanalysis (TGA),Raman spectroscopy,Scanning Electron Microscopy (SEM),Field Emission Scanning Electron Microscopy(FESEM),Atomic Force Microscopy(AFM),High performance liquid chromatography(HPLC).

The covalent attachment of Naltrexone to multi-walled carbon nanotubes byoxalyl chloride agent

Mohammadreza Gholibeikian, Amirreza Arvaneh, Nastaran GholamiSamalic — Mon, 14 Mar 2022 00:00:00 +0000

This work presents a novel cascade of chemical functionalization of multi-walled carbon nanotubes(MWCNTs) through chemical modification by an opioid antagonist drug of Naltrexone. Naltrexone-conjugated MWCNTs were synthesized involving the sequential steps of carboxylation, acylation,and finally,Naltrexoneconjugation.The active acyl chlorides in MWCNTs were subsequently mixed with opioid antagonist drug of Naltrexone.The modification of MWCNTs with Naltrexone was investigated by Fourier transform-infrared spectroscopy,Raman spectroscopy,Thermo Gravimetric Analysis,Elemental Analysis,High Performance Liquid Chromatography.Size and surface characteristics of chemically modified MWCNTs were monitored by Transmission Electron Microscopy,Scanning Electron Microscopy,Field Emission Scanning Electron Microscopy,Atomic Force Microscopy.

Study and optimization of Diels-Alder reaction of piperine in aqueous ionic solutions using Gn.HCl as a catalyst

Ramasubbarao Vidadala — Sun, 31 Jan 2021 00:00:00 +0000

Study and optimization of Diels-Alder reaction of piperine in aqueous ionic solutions using Gn.HCl as a catalyst. The semi-synthesis of these products using intermolecular [4+2] cycloaddition reaction has been described. Obtained products were characterized using IR, HNMR, CNMR and Mass Spectroscopy.

Synthesis of β-keto-sulfones using alkyl/aryl sulphinates in ionic liquids [bmim-BF4] as an efficient and reusable reaction medium

Suryakiran Navath — Sun, 31 Jan 2021 00:00:00 +0000

Synthesis of b-keto-sulfones using alkyl/aryl sulphinates in ionic liquids as en efficient and reusable medium is described. Reaction of α-haloketones with sodium alkyl/aryl sulphinates in ionic liquid afforded the corresponding sulfones in excellent yields. Obtained products were characterized using IR, ¹HNMR, ¹³CNMR and Mass Spectroscopy.

What to Expect in the Next Green Revolution?

Suryakiran Navath — Tue, 13 Jul 2021 00:00:00 +0000

A green revolution is much needed and long overdue. Here’s what scientists aresearchers need to focus on